Spexib (Ceritinib)

1. What is Spexib used for?

Spexib (generic name: **Ceritinib**) is a medication used for the treatment of **non-small cell lung cancer (NSCLC)** that has spread to other parts of the body. It is specifically effective for patients with **ALK-positive** NSCLC, meaning the cancer cells have a mutation in the **ALK gene**. **Spexib** works by blocking the action of the mutated **ALK protein**, which is responsible for the growth and spread of cancer cells.

2. How does Spexib work?

Spexib contains **Ceritinib**, which is a **tyrosine kinase inhibitor** that targets the **ALK** protein. By inhibiting the activity of the **ALK protein**, **Spexib** prevents the uncontrolled growth of cancer cells, thereby helping to slow down or stop the progression of **ALK-positive non-small cell lung cancer (NSCLC)**. This targeted therapy is more effective than traditional chemotherapy for this specific genetic mutation.

3. How should I take Spexib?

Spexib is taken **orally** in the form of a **capsule**. The typical recommended dose is **750 mg once daily**, but your doctor may adjust the dose based on your health condition and how well you tolerate the medication. The capsule should be swallowed whole with food. Do not crush, chew, or open the capsule. Be sure to follow your doctor’s instructions regarding dosage and timing.

4. What are the common side effects of Spexib?

Common side effects of **Spexib** may include:

• Diarrhea
• Fatigue or **tiredness**
• Loss of appetite
• Abdominal pain or **nausea**
• Rash or **itching**

In some cases, more severe side effects may occur, such as **liver toxicity**, **lung problems**, or **heart rhythm issues**. If you experience any serious side effects, seek medical attention immediately.

5. Can I take Spexib with other medications?

Spexib can interact with other medications, especially those that affect liver enzymes (such as **cytochrome P450 enzymes**) or other cancer therapies. Be sure to inform your doctor about all other medications you are currently taking, including **prescription**, **over-the-counter drugs**, and **herbal supplements**. Your doctor will monitor potential drug interactions and may adjust your treatment plan accordingly.

6. Is Spexib safe during pregnancy or breastfeeding?

Spexib should not be used during pregnancy as it may cause harm to the fetus. It is classified as a **Pregnancy Category D** drug, indicating that it can harm the unborn baby. It is also not recommended during breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before starting treatment with **Ceritinib**.

7. How long should I take Spexib?

The duration of treatment with **Spexib** depends on your individual condition and response to therapy. It is usually taken as a **long-term** treatment for **ALK-positive non-small cell lung cancer (NSCLC)**. Your doctor will monitor your health and may adjust your treatment plan based on the effectiveness of the medication and any side effects you may experience.

8. What should I do if I miss a dose of Spexib?

If you miss a dose of **Spexib**, take it as soon as you remember, unless it is almost time for your next dose. **Do not take two doses** to make up for a missed dose. If you are unsure what to do, contact your healthcare provider for advice.

9. Are there any precautions when using Spexib?

Before taking **Spexib**, inform your doctor if you have any of the following conditions:

• Liver disease or **liver problems**
• Heart issues, including **QT prolongation** (a heart rhythm disorder)
• Respiratory conditions, such as **pneumonitis**
• History of vision problems

Your doctor will assess whether **Spexib** is appropriate for you and monitor you for potential side effects throughout your treatment.

10. Where can I buy Spexib?

Spexib (Ceritinib) is available by prescription only. It can be purchased from licensed pharmacies with a valid prescription. Be sure to purchase from a reputable source to ensure the authenticity and safety of the medication.